Several biological mechanisms link obesity and BC risk, such as obesity increases insulin resistance, hyperinsulinemia, growth hormone secretion, the production of carcinogens (mitogenesis, mutagenesis, angiogenesis, reduced apoptosis, metastasis, and immunosuppression), oxidative stress, and the inflammatory processes (48). This evidence concerns the gene GH1 and obesity due to melanocortin 4 receptor deficiency.