In gastric cancer cells, circHIPK3 contributes to cisplatin resistance by inhibiting autophagy-dependent ferroptosis, while silencing circHIPK3 enhances ferroptosis through the miR-508-3p/Bcl-2/Beclin1/SLC7A11 axis, reducing cisplatin resistance (Shang et al., 2023). The gene discussed is SLC7A11; the disease is gastric cancer.