RIPK1 and ovarian carcinoma: In pancreatic and ovarian cancer cells, 6-methoxydihydroavicine activates the RIPK1/caspase axis leading to disruption of oxaloacetic acid metabolism (Ma et al., 2022) and alters mitochondrial respiration to induce MAPK-mediated apoptosis (Ma et al., 2022; Zhang et al., 2016).