Furthermore, men who are homozygote for the rare allele for the VDR SNP rs2238135 have a 2-fold higher risk of prostate cancer compared with those who are homozygote for the common allele (95% CI: 1.17–3.26; p = 0.007 (Holick et al., 2007). This evidence concerns the gene VDR and prostate carcinoma.