Interestingly, CYP27A1 and CYP2R1 expressions are higher in endometrial carcinoma compared to normal endometrium, but they are still inversely with the proliferation marker Ki67, and vitamin D treatment reduces cell viability and colony number in vitro, suggesting that CYP27A1 and CYP2R1 are beneficial factors for endometrial carcinoma patients in consistence with previous observations (Bergadà et al., 2014). The gene discussed is CYP27A1; the disease is endometrial carcinoma.