CYP3A4 and mature T-cell and NK-cell non-Hodgkin lymphoma: Similarly, expression of CYP3A4 and P-glycoprotein (MDR1) correlates with poor clinical response in peripheral T-cell lymphoma (PTCL), and high CYP3A4 expression correlates with lower complete remission rates, suggesting its role in predicting therapeutic responses to standard PTCL chemotherapy (Rodríguez-Antona et al., 2007).