CYP3A4 and cancer: Li-Ping Zhou et al. investigated the association between CYP3A4*1B (rs2740574A > G) polymorphism in a meta-analysis involving 3,810 cancer patients and 3,173 healthy controls, and they discovered that G allele and G/G genotype were associated with increased risk of cancers (allele model: OR = 1.24, 95 %CI: 1.09–1.42, p = 0.001; recessive model: OR = 1.77, 95 %CI: 1.30–2.41, p < 0.001; homozygous model: OR = 1.72, 95 %CI: 1.19–2.47, p = 0.004).