Parallelly, Jing Wen et al. conducted a meta-analysis covering 23,780 cancer cases and 27,307 controls on 3 SNPs of CYP2R1 (rs10741657 G/A, rs12794714 G/A, and rs2060793 G/A) and did not identify significant correlation with overall cancer risk, but further stratified analyze revealed that CYP2R1 rs12794714-G/A SNP was associated with a significantly lower risk of colorectal cancer (A vs. G: OR = 0:866, 95% CI: 0.753–0.997, p = 0.046) (Wen et al., 2021). The gene discussed is CYP2R1; the disease is cancer.