For example, a study on multidrug resistance-associated proteins demonstrated that CYP3A4 overexpression would lead to the acquisition of doxorubicin resistance in human prostate cancer LNCaP, osteosarcoma MG-63, and chondrosarcoma SW-1353 cells (Tian and Hu, 2015; Ohya et al., 2023). This evidence concerns the gene CYP3A4 and Familial prostate cancer.