Haojie Li et al. reported that Men with a low serum vitamin D status and a less active VDR genotype were at approximately two-fold higher risk for prostate cancer than men with the active VDR allele and a high serum 5 (OH)D3 in a prospective study involving 18 years of follow-up of 14,916 men initially free of diagnosed cancer in United States (Li et al., 2007). The gene discussed is VDR; the disease is prostate carcinoma.