CYP2R1 and endometrial carcinoma: Interestingly, CYP27A1 and CYP2R1 expressions are higher in endometrial carcinoma compared to normal endometrium, but they are still inversely with the proliferation marker Ki67, and vitamin D treatment reduces cell viability and colony number in vitro, suggesting that CYP27A1 and CYP2R1 are beneficial factors for endometrial carcinoma patients in consistence with previous observations (Bergadà et al., 2014).