reported that CD47 knockdown reduced the expression of alpha-smooth muscle actin (α-SMA) and collagen I(COL1A1)by inhibiting the AKT/mTOR signaling pathway in a high-fat diet-induced mouse model of MASLD, thus preventing HSC activation and reducing liver fibrosis, similar to previous findings. The gene discussed is CD47; the disease is metabolic dysfunction-associated steatotic liver disease.