XIAP and hyperinsulinemic hypoglycemia, familial, 4: In the context of CD, the identification of lesions involving multiple sites advocates for the prompt initiation of biologic therapies, which may significantly impact treatment protocols.32,33 For the purpose of the differential diagnosis of monogenic IBD, including conditions such as CEAS, interleukin-10 deficiency, and XIAP deficiency, a holistic diagnostic strategy that encompasses the evaluation of the small intestine is essential.34 Considering these factors, SBCE may possess significant clinical value in the management of VEO-IBD.