Younger age (41 years [33–51] vs. 47 [39–56], p = 0.011), higher TSH receptor antibody (TRAb) at diagnosis (8.8 IU/L [4.9−17.2] versus 6.0 [4.1−9.9], p = 0.002), higher TRAb at cessation of ATD (1.3 [<0.9–2.3] vs. 1.0 [<0.9–1.3], p < 0.001), longer time to normalisation of TSH (6 months [3–9] vs. 4 [2–7], p 0.013) and longer time to normalisation of fT4 (2 months [1−3] vs. 1 [1−2], p = 0.001) were all associated with relapse within 10 years. This evidence concerns the gene TSHR and Jeune syndrome.