TP53 and cancer: TP53 is among the most frequently mutated genes in cancer cells, and its mutant forms contribute to tumor progression by enhancing cancer cell proliferation, migration, invasion, metabolic reprogramming, and angiogenesis.[39] The high TMB + low-risk cohort had the best prognosis, whereas the low-TMB + high-risk cohort had the worst, according to the survival analysis coupled with TMB and risk ratings.