TRDMT1 and renal carcinoma: This kind of RNA modification process is reversible and is primarily governed by the m5C methyltransferase complex (writers), including the NSUN family (NSUN1-NSUN7) and TRDMT1 (DNMT2), m5C demethylase enzymes (erasers) such as ALKBH1, and the TET family and m5C reading proteins (readers) such as ALYREF and YBX1.[6] Several studies have found that m5C-regulated proteins can participate in immune infiltration of renal cancer cells and are associated with patient prognosis.[7,8]