After adjusting for hypertension, diabetes, triglyceride levels, gender, and age, Student t tests covariance confirmed significant differences in the enrichment levels of TWEAK, TNF-α, IL-10, and IL-4 of patients in case group (PTWEAK = .017, PTNF-α < .001, PIL-10 = .010, PIL-4 = .016). The gene discussed is TNF; the disease is diabetes mellitus.