Abnormal expression or function of NCOA1 may affect cardiac contractility and relaxation, potentially contributing to the development of CHD,[36] and additionally, NCOA1 may influence the development of CHD through its effects on the inflammatory response.[37] RXRA is primarily associated with vitamin A metabolism and signaling, but research has confirmed[38] that under conditions of atherosclerosis, RXRA expression and function may be altered, affecting plaque stability and the inflammatory response. This evidence concerns the gene NCOA1 and coronary artery disorder.