Blocking TNF signaling can alleviate inflammation and stabilize atherosclerotic plaques.[60] The HIF-1 signaling pathway serves a crucial function under hypoxic conditions, participating in angiogenesis[61] and regulating the occurrence and development of atherosclerosis.[62] The IL-17 signaling pathway is important in the pathogenesis of CHD. The gene discussed is IL17A; the disease is coronary artery disorder.