HLA-B*13:01 specifically binds dapsone and activates dapsone-specific cytotoxic T lymphocytes in an HLA-B*13:01-dependent manner.[22] It is noteworthy that HLA genes are also closely associated with susceptibility to leprosy,[23] potentially elucidating why DHS is prevalent among leprosy patients and tends to manifest more severely in this group. Here, PPIB is linked to leprosy.