The study found that TDP-43 is the main disease protein in the 2 diseases, further demonstrating the crucial role of TDP-43 in these neurodegenerative diseases and providing important clues and a foundation for the research and treatment of related diseases.[18] 16 Among the 855 journals from which the references were cited, the minimum citation frequency for a single journal was set at 50 times. The gene discussed is TARDBP; the disease is neurodegenerative disease.