TARDBP and amyotrophic lateral sclerosis: Trojanowski, has the largest number of publications, and his research focus is concentrated on unraveling the pathomechanisms of FTLD-ALS, in particular the aberrant aggregation and ubiquitination modification of the TDP-43 protein and its role in neurodegenerative diseases.[20–27] These studies provide in-depth insights into the pathogenesis and pathological features of FTLD-ALS, and offer potential targets and clues for future diagnosis and treatment.