The core findings of these 7 articles mainly focused on the multiple modifications (e.g., ubiquitination, phosphorylation), inclusion body formation of TDP-43 protein during the pathological process of FTLD and ALS, as well as the differences in its pathological features in different neurological regions.[18–20,28–31] These studies revealed the key role of TDP-43 protein in the pathogenesis of FTLD-ALS, which provides an important basis for understanding the pathological basis of the disease, discovering diagnostic markers and exploring potential therapeutic targets. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.