Both studies found that ubiquitin-positive and tau-negative neuronal cytoplasmic inclusions, etc, are common pathological features of FTLD-ALS, and determined that TDP-43 is an important related protein and there are abnormal modification changes such as phosphorylation, supporting the view that these 2 neurodegenerative diseases have an internal connection and can be classified into 1 category.[18,19] From 2008 to 2013, the number of published articles was stable at 5 to 12, with an average citation frequency of 54 to 241 times, and the field developed steadily. This evidence concerns the gene TARDBP and neurodegenerative disease.