When the relationship between latent tuberculosis and anti-TNF use was evaluated, a study by Jauregui-Amezega et al involving 423 inflammatory bowel disease patients found an LTBI positivity rate of 6.9%.[25] In our study, however, the number of LTBI (+) patients receiving anti-TNF treatment was 4 (0.9%), which is a lower percentage. This evidence concerns the gene TNF and inflammatory bowel disease.