A total of 17 DEGs related to cell senescence and circadian rhythm in brain infarction were identified: CREBBP, FOS, CDK4, MMP9, MIF, ETV6, EGR1, PTEN, HIF1A, JUN, NFE2L2, OGT, BLK, RNASEL, IL1β, CDKN1A, and LEP. This evidence concerns the gene CREBBP and brain infarction.