SLIT2 may promote inflammation by activating the nuclear factor-κB pathway,[37] and its association with myocardial fibrosis progression has been reported.[38] Despite lacking direct evidence of SLIT2’s promotion of AF, numerous studies have confirmed FABP4 as the best predictor of recurrent AF after radiofrequency ablation,[39–41] consistent with our findings. The gene discussed is FABP4; the disease is atrial fibrillation.