CDC20 (cell division cycle 20) is a cell cycle regulatory protein that forms an E3 ubiquitin ligase by binding to the Anaphase-Promoting Complex/Cyclosome (APC/C), and regulates cell mitosis by controlling substrate degradation.[41] A further key gene, CCNB2, has been identified as a cell cycle protein that is primarily involved in the G2/M phase transition.[42] A substantial body of research has established a strong association between CCNB2 function and a variety of tumor prognosis and pathogenesis. This evidence concerns the gene CDC20 and neoplasm.