KDM5C and colorectal carcinoma: To validate the role of DLG4 in HOXC‐AS3/KDM5C‐regulated CRC cell proliferation, the DLG4 expression in cells was downregulated and combined experiments were carried out using si‐DLG4*1 and si‐KDM5C*1, which showed improved transfection efficiency (p < 0.01, Figure 5A,B).