Apart from PD, LRRK2 has been a hot topic of discussion for autoimmune diseases such as IBD, type 1 diabetes, rheumatoid arthritis, celiac disease, psoriasis, and multiple sclerosis, which LRRK2 modulates multiple pathways in innate and adaptive immunity by hindering NF-κB and NF-AT signaling [142]. This evidence concerns the gene LRRK2 and Parkinson disease.