LRRK2 and colon carcinoma: The obtained results indicated increasing quantities of each compound followed by a decrease of Rab8a phosphorylation, indicative of inhibited LRRK2 kinase activity [226] to test OPM-38 as an LRRK2 inhibitor, SH-SY5Y neuroblastoma cells were transfected with hG2019S or hWt LRRK2, manifesting colon carcinoma.