DYRK1A and Alzheimer disease: Among these, three interventional studies to improve cognition and reduce neurodegeneration aim to target chromosome 21-encoded DYRK1A (Dual specificity tyrosine-phosphorylation-regulated kinase 1 A) through the nutraceutical epigallocatechin-3-gallate in green tea extract, and one trial focuses on an anti-AD vaccine, ACI-24 (Supplementary Table 2, Tab 1).