Our cell communication analysis based on the curated receptor-ligand pair database showed that fibroblast in vestibular schwannoma microenvironment mainly regulated the biological behavior of tumor cells through PSAP/GPR37L1, MDK/(ITGA6 + ITGB1), IGF2/(ITGA6 + ) and MDK/LRP1 signaling axes. This evidence concerns the gene IGF2 and Vestibular schwannoma.