LGR5 and Barrett esophagus: We further validated our results in vivo using the previously described IL1β-induced Lgr5-CreERT2; p16flox/flox/KrasG12D mouse model, which reliably reproduces the histological progression of Barrett’s-like dysplasia in the squamocolumnar junction (SCJ), confirming SNHG1’s critical role in regulating EMT and BE progression.