Additionally, silencing SOX2 in tumor-initiating cells (TICs) reduces tumor proliferation and tumorigenicity, emphasizing its functional importance in GBM progression.161,162 These findings underscore the importance of SOX2 as a biomarker for glioma classification and prognosis while highlighting its potential as a therapeutic target to improve treatment outcomes in aggressive brain tumors. Here, SOX2 is linked to glioblastoma.