NOTCH1 and glioblastoma: Inhibiting Notch1 has shown promise in reducing tumor hypoxia and sensitizing GBM to radiotherapy.296 The convergence of the Notch pathway with the PDGF and nitric oxide signaling pathways highlights additional regulatory mechanisms that sustain GSCs and GBM progression.295 Understanding the context-dependent role of Notch in GBM could facilitate the development of more precise therapeutic interventions and prognostic markers for patient stratification.