METTL3 and neoplasm: Additionally, circRNA_0037655 and circ-MAPK4 promote tumor survival and invasion,57 whereas circ-E-cadherin and circ-XRCC5 are linked to GBM aggressiveness and poor prognosis.58 In contrast, circ-DCL1 suppresses tumor proliferation through METTL3-mediated m6A modification,59 highlighting the dual role of circRNAs as oncogenes and tumor suppressors.