FASN and neoplasm: Pseudopalisading regions in GBM accumulate fatty acids via FABP3/7, supporting tumor invasion and angiogenesis.234 Emerging evidence suggests that targeting fatty acid synthase (FASN)235 and polyunsaturated fatty acid (PUFA) synthesis may provide therapeutic benefits.236 Nitrogen metabolism is also altered in GBM, with dysregulated glutamine and cysteine metabolism contributing to tumor growth and resistance.