STAT3 and neoplasm: Its activation is linked to KLHL9 deletions and EGFR signaling, positioning it as a central player in tumor progression.305 In conjunction with STAT3, C/EBPβ drives mesenchymal differentiation, enhancing GBM cell invasion, proliferation, and survival.192 C/EBPβ contributes to GBM pathobiology by regulating DNA damage responses and inducing genes associated with invasion and metastasis.