Additionally, c-Myc enhances tumor vascularization by upregulating miR-9 and facilitates GBM cell invasion through RhoA activation.308,309 In addition to its role in tumor progression, c-Myc is a central regulator of GBM metabolism, driving a shift toward glycolysis to sustain energy production under hypoxic conditions. The gene discussed is MYC; the disease is neoplasm.