This alteration, driven by histone modifications at the EGFR enhancer region on chromosome 7p12, contributes to uncontrolled tumor growth and resistance to apoptosis.135 EGFR-mediated activation of the RTK/RAS/PI3K signaling axis disrupts the G1/S checkpoint, facilitating unchecked cell cycle progression.136 Patients with EGFRvIII mutations exhibit worse survival outcomes than those with wild-type EGFR, with coexpression of both forms further exacerbating tumor aggressiveness. This evidence concerns the gene PIK3CA and neoplasm.