Mechanistic studies have identified FOXA2 as a key target of miR-124a, linking its downregulation to apoptotic pathways and tumor suppression.447 Additionally, engineering GBM cells to express miR-302 and miR-367 profoundly affects the surrounding tumor environment, leading to decreased proliferation, reduced tumorigenicity, and the modulation of stemness markers in neighboring GBM cells.448 When implanted alongside GBM stem cells, these engineered cells significantly inhibited tumor growth in vivo. The gene discussed is FOXA2; the disease is glioblastoma.