Distinct patterns of Wnt pathway gene hypermethylation in primary and secondary GBMs suggest subtype-specific regulatory differences.285 Studies have also reported that the overexpression of Wnt ligands (Wnt2, Wnt3a, and Wnt5a), Frizzled receptors, and β-catenin in GBM correlates with tumor grade and poor patient outcomes. The gene discussed is WNT2; the disease is neoplasm.