circ-NEIL3 stabilizes insulin-like growth factor (IGF)-2 mRNA binding protein 3, facilitating exosomal transfer to TAMs and thereby reinforcing their immunosuppressive functions.60 Moreover, circ-LGMN, which is significantly upregulated in HGGs, drives GBM malignancy by regulating legumain.61 The identification of circRNAs as potential biomarkers presents promising opportunities for noninvasive GBM diagnosis and personalized treatment strategies. The gene discussed is LGMN; the disease is glioblastoma.