Its efficacy is linked to PTGR1 expression, EGFR signaling, and low NER/ERCC3 levels, while spironolactone enhances its cytotoxic effects, suggesting a potential combination therapy for GBM.358 Similarly, LMP400 shows high efficacy in PTEN-null GBM, inducing G2/M cell cycle arrest, DNA damage, and apoptosis. This evidence concerns the gene ERCC3 and glioblastoma.