IDH2 and glioma: Advances in genome-wide methylation profiling have significantly improved tumor classification, prognosis, and treatment stratification.110 DNA methylation patterns provide insights into molecular subtypes, with studies demonstrating their accuracy in predicting key glioma features such as IDH mutations and 1p/19q codeletions.111 These findings highlight methylation profiling as a powerful diagnostic and prognostic tool that complements histopathological classification.