Additionally, NF-κB signaling is sustained by epithelial V-like antigen 1 (Eva1), which maintains GSC characteristics through the regulation of stemness-associated genes.270,271 In addition to its role in tumor maintenance, NF-κB promotes the mesenchymal phenotype of GBM by activating key transcription factors, including STAT3, CCAAT/enhancer-binding protein β (C/EBPβ), and TAZ. The gene discussed is STAT3; the disease is glioblastoma.