It enhances the replicative potential of GBM cells by activating TERT and promotes resistance to TMZ and radiotherapy by upregulating MGMT expression.300 Given its multifaceted role in GBM progression, targeting aberrant Hh signaling—particularly tGLI1—may offer promising therapeutic strategies to counteract metastasis and treatment resistance. The gene discussed is MGMT; the disease is glioblastoma.