Importantly, it contributes to resistance against radiation and TMZ by upregulating DNA repair proteins such as Nibrin (NBS1) and Reversionless 3-like (REV3L), enabling tumor cells to withstand genotoxic stress.310 Given its broad oncogenic influence, targeting c-Myc represents a promising therapeutic strategy in GBM. The gene discussed is MYC; the disease is glioblastoma.