Additionally, we used the MDA-MB-468 cell line with stable 66CTG knockdown (Supplementary Fig. 4f, g) to generate a tumor model of TNBC orthotopic xenograft in nude mice, and found that the knockdown of 66CTG significantly suppressed the growth of TNBC xenograft tumor (Fig. 4d–f) and diminished the c-Myc and Cyclin D1 expression in xenograft tumor tissues (Supplementary Fig. 4h, i). This evidence concerns the gene MYC and neoplasm.