Among these, PTENα regulates mitochondrial energy metabolism,64 PTENβ is involved in ribosomal DNA transcription and promotes ribosome biogenesis,65 and PTENε inhibits tumor metastasis by regulating filopodia formation.66 In this study, we revealed that CDKN2B-AS1 initiated the translation of the 66CTG peptide via CUG, which upregulated Cyclin D1 by stabilizing c-Myc, thereby promoting TNBC cell proliferation and tumor growth. Here, PTGDR is linked to neoplasm.