TP53 and colorectal carcinoma: Similarly, it was found that the lncRNA HMG is elevated in CRC and correlated with chemotherapy resistance in CRC patients, lncRNA HMG is activated by the wnt/β-catenin signaling pathway, which up-regulates ferroptosis inhibitors SLC7A11 and VKORC1L1 through inhibits p53, in turn suppresses ferroptosis and chemotherapy resistance in CRC cells [171].