GPX4 and colorectal carcinoma: In addition, a study found that miR-15a-3p can directly inhibit GPX4, resulting in tumor cells with increased Fe2+ levels and ROS, which in turn contributed to ferroptosis and suppressed the proliferation, invasion, and migration of tumor cells, however, miR-15a-3p expression was down-regulated in CRC cells, which led to the development of CRC [146].