AKT1 and colorectal carcinoma: For example, adenomatous polyposis coli membrane recruitment 1 deficiency facilitates distant metastasis of CRC by suppressing SLC7A11 and ferritin light chain-mediated ferroptosis [105]; krüppel-like factor 2 induces ferroptosis in CRC through the PI3K/AKT signaling pathway, thereby inhibiting its metastatic ability [106].