NFE2L2 and colorectal carcinoma: Similarly, it was demonstrated that LINC00239, an inhibitor of ferroptosis, is overexpressed in CRC and is related to an adverse prognosis of CRC patients, LINC00239 activates the NF-E2-related factor 2 signaling pathway by interacting with Kelch-like ECH-associated protein 1, which inhibits ferroptosis and promotes proliferation of CRC cells [154].