DVL1 and neoplasm: At specific exonic regions, DVL1 binding overlapped with histone markers commonly associated with active enhancers (H3K27ac, H3K4me1), active promoters (H3K4me2, H3K4me3, H3K9ac), and other markers of gene transcription (H3K36me3, POL2RA) in genes linked to tumor progression and metastasis32–34, hormone dysregulation linked with tumorigenesis35 and developmental disorders36 and Wnt signaling37.