Hepatocyte growth factor (HGF), also produced by stromal endometrial cells (Sugawara et al., 1997), supports the growth and proliferation of epithelial and stromal cells in the endometrium, and unregulated HGF/c-MET/Akt pathway activation is even shown to drive carcinogenesis in endometrial carcinoma (Li et al., 2015). This evidence concerns the gene AKT1 and endometrial carcinoma.