HSD17B2 and Infertility: Similarly, studies using EEOs from patients with infertility showed that these patients have reduced expression of receptivity markers, including hydroxysteroid 17-beta dehydrogenase 2 (HSD17B2), FOXO1, and MUC1 in response to treatment with oestradiol, progestin, and cAMP, suggesting a dysregulated response in hormone-responsive genes (Zhou et al., 2022).