While blocking NLRP3 activity with MCC950, which crosses the blood–brain barrier (Fan et al., 2018; Martínez-Martel et al., 2025), has been shown to reverse allodynia in female PAE mice (Noor et al., 2023), it remains unclear whether this prolonged allodynia results from peripheral and/or central immune signaling and how MCC950 exerts its beneficial effects. This evidence concerns the gene NLRP3 and pulmonary artery enlargement.