GABRG2 and cancer: Based on the literature, ACBP/DBI can mediate cell-autonomous cancer cell-supportive metabolic effects, as indicated by the fact that glioblastoma growth was enhanced by transfection with the wild-type ACBP/DBI protein but not by a mutant (K32A) that lacks acyl-CoA binding capacity and fails to stimulate fatty acid oxidation,18 but still is able to bind to GABRG2 and to mediate metabolic effects when injected into mice.21