That said, it appeared that the knockout of ACBP/DBI had more consistent oncosuppressive effects than F77I GABRG mutation and vaccination with KLH-ACBP/DBI against hepatocarcinogenesis induced by oncogenes (Myc plus Ctnnb1) or hepatic damage (by WD plus CCl4), arguing in favor of the importance of both pools of ACBP/DBI. This evidence concerns the gene CTNNB1 and Wilson disease.