The current study was designed to expand upon these findings and better characterize the contribution of insertional mutagenesis of STAT3 to HIV + T cell clonal expansion by assessing STAT3 and STAT3-related genes at a transcriptional and protein level and compare in vitro infected cells to T cell lymphomas with similar integration sites from PWH. This evidence concerns the gene STAT3 and T-cell non-Hodgkin lymphoma.