Continued risk of NHL has been thought to be triggered by ongoing immune dysregulation and expression of HIV proteins by PWH on ART [21–23]; However, there is one published example of an AIDS-associated B cell lymphoma with a clonal integration of an HIV provirus in intron 1 of STAT3 [16], a gene whose misexpression is commonly associated with non-HIV-associated lymphomas [24]. Here, STAT3 is linked to lymphoma.