While this study focuses on time since last birth, further investigation of these variables is warranted [7,8].Some pregnancy-related factors, like placental growth factor (PlGF) and placenta-specific protein 1 (PLAC-1), have been linked to endometrial cancer [9–13], and associations with pregnancy-related Wnt signaling or Homeobox (HOX) genes have also been observed [2,14,15]. Here, PLAC1 is linked to endometrial cancer.