Histone H3 lysine 9 trimethylation (H3K9me3) loss at the D4Z4 is associated with FSHD [27] and loss of histone lysine methyltransferase (HKMT) SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) and Tripartite Motif Containing 28 (TRIM28), which complexes with HKMT Suppressor of Variegation 3–9 Homolog 1 (SUV39H1), led to increased DUX4 expression in myoblasts [26, 28]. This evidence concerns the gene TRIM28 and Facioscapulohumeral dystrophy.