TNF and Bloom syndrome: In addition, intracytoplasmic FACS analysis revealed an increase in the level of the Treg activation–associated cytokine IL-10 (Figure 5B) and no significant increase in the production of other cytokines, including IFN-γ, TNF-α, and IL-6 (Supplemental Figure 12A, C, and E), suggesting the suppression of inflammation in BLM-induced PF.