PRF1 and pemphigus foliaceus: CAR-cTregs were constructed to effectively eliminate FAP1+ Fibs (aFibs) via the granzyme B (GZMB)/perforin (PFP) pathway and reverse bleomycin-induced (BLM-induced) PF, which is characterized by diminished recruitment of fibrocytes and improved remodeling of epithelial cells.