Interestingly, one study found SCLC-A and SCLC-N subsets to have mesenchymal features distinct from the non-NE subset (65), which corresponds with our finding that NOTCH1-driven EMT is specific to ASCL1- and NEUROD1-enriched tumors, rather than non-NE-enriched tumors. The gene discussed is NEUROD1; the disease is small cell lung carcinoma.