As in our human SCLC cell line model, long-term KP1 TAS1440–treated cells upregulated Notch signaling, induced EMT based on increased expression of Vim and the cell surface-marker Cd44, increased cell-surface MHC class I, and increased APM gene expression (Supplemental Figure 9, A–C). The gene discussed is CD44; the disease is small cell lung carcinoma.