Strikingly, KP1 DMSO and KP1 TAS plus GSI tumors were immune excluded, with CD3+ and CD8+ T cells restricted predominantly to the tumor margin, whereas KP1 TAS1440 tumors were immune inflamed, with abundant infiltration of CD3+ and CD8+ T cells within the interior of the tumor (Figure 5E), which was also evident in the KP1-A model (Supplemental Figure 9I). The gene discussed is CD8A; the disease is neoplasm.