NOTCH1 and lung cancer: As MYC has been shown to be a driver of Notch signaling in SCLC (29) and may impair response to ICB in lung cancer (30), we examined MYC expression across these subsets and found very high MYC expression in SCLC-P, but not in SCLC-I or SCLC-A/N (Figure 2B), and no difference in MYC expression between NE-enriched tumors stratified by NOTCH1 expression (Figure 2C).