To validate these results, we performed differential gene expression analysis between NE-enriched and non-NE-enriched subsets among a combined cohort of limited-stage SCLC tumors (23, 31) and similarly found NOTCH2, but not NOTCH1, to be enriched among the non-NE-enriched subset (excluding POU2F3-high tumors) (Supplemental Figure 6C). Here, NOTCH1 is linked to small cell lung carcinoma.