Given that Notch signaling is dose dependent and N1ICD overexpression may not represent normal physiologic N1ICD levels (34), we next used pharmacologic activation of Notch signaling through LSD1 inhibition (35) as an orthogonal approach to assess the relationship among NOTCH1, EMT, and antigen presentation in SCLC. Here, NOTCH1 is linked to small cell lung carcinoma.