Analysis of inflammatory mediators in NHBE culture supernatants (Luminex multiplex assay) revealed that IL1β, IL1α, and CXCL1 were significantly elevated in NHBEA/A cultures compared to NHBEG/G cultures following infection with Cal/09 and HK/68 (Fig. 3 F and G). The gene discussed is CXCL1; the disease is infection.