Genes such as SUFU, which harboured an lpVUS in one of the patients diagnosed at 22 years of age, is known for its association with Gorlin syndrome, while ASXL1 and NOTCH2, identified in another patient, have been implicated in familial CRC [31, 32, 36]. The gene discussed is ASXL1; the disease is nevoid basal cell carcinoma syndrome.