The datasets were further selected for the unaltered 14-known genes of hereditary CRC (APC, BMPR1A, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, and TP53) but with altered genes of the lpVUS cases that were identified in this study to observe their clinical or mutational features. The gene discussed is SMAD4; the disease is colorectal carcinoma.