CD40LG and neuropathy: The HNK-1 epitope is a trisaccharidecomposed of a 3-O-sulfated glucuronic acid linkedto N-acetyllactosamine (HSO3-3GlcAß1–3Galß1–4GlcNAc-).Earlier studies have shown that disease progression arises from directtargeting of pathogenic IgM autoantibodies to HNK-1-containing glycoconjugates.However, the exact mechanism by which IgM neuropathy occurs has notbeen fully elucidated.