CXCL8 and neoplasm: Chemokines like CXCL-8 and CXCL1/2/5 in the tumor microenvironment attract neutrophils to infiltrate late-stage tumors, where they release reactive oxygen species (ROS) to induce DNA damage and secrete vascular endothelial growth factor (VEGF) to accelerate angiogenesis (35, 36).