In addition, studies have found that Streptococcus gallolyticus can stimulate colon cancer cells to release IL-8 (43), while Fusobacterium nucleatum induces the secretion of IL-8 and CXCL1 by host cell binding and invasion (44), promoting the migration of colorectal cancer cells and highlighting the synergistic role of the gut microbiota and chemokines in CRC. This evidence concerns the gene CXCL8 and colorectal cancer.