CXCL8 and malignant colon neoplasm: In addition, studies have found that Streptococcus gallolyticus can stimulate colon cancer cells to release IL-8 (43), while Fusobacterium nucleatum induces the secretion of IL-8 and CXCL1 by host cell binding and invasion (44), promoting the migration of colorectal cancer cells and highlighting the synergistic role of the gut microbiota and chemokines in CRC.