For instance, in the comparison between PCa tumor and normal samples, DiCE identified 61 cancer fitness genes, including MYC, CCNA2, PLK1, PTTG1, EPCAM, and MTOR, that were overlooked by typical DEA but are well-documented contributors to PCa progression (Supplementary Table S1) [39, 56–75]. This evidence concerns the gene MYC and cancer.