An increase in the betweenness centrality of a node/gene in tumor samples indicates that the gene lies on shorter paths connecting other genes, suggesting its role as a bridge in tumor-related PPIs (Fig. 2B), for instance, VCL, FLNA, TNS1, GATA3, and ITGB3, which may act as key connectors in tumor samples. Here, ITGB3 is linked to neoplasm.