These genes clustered around the 14-3-3 gene Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein β (YWHAB) when assembled into an Ingenuity Pathways Analysis (IPA) gene interaction network, suggesting a pivotal role for this gene in the differential response to HPgV in PD-WT and PD-LRRK2 patients. The gene discussed is YWHAB; the disease is Parkinson disease.