FUBP3, a nucleic acid binding protein known to interact with the flavivirus JEV and limit neuronal activation of NLRP3 inflammasome (30, 31), was decreased in PD HPgV– patients compared with other groups, but it was similar in PD HPgV+ and CT (Figure 4A, adjusted P (Padj) = 0.005). This evidence concerns the gene NLRP3 and Parkinson disease.