Specifically, our recent findings have demonstrated that GSC/GBM cell–derived cytokines (e.g., LOX, OLFML3, LGMN, TFPI2, and CCL2/CCL7) are important to generate a context-dependent GSC-TAM bidirectional interaction, inducing a protumor TME (13–17). The gene discussed is TFPI2; the disease is glioblastoma.