Furthermore, our recent studies demonstrated that PTEN deletion/mutation and metabolic alteration in GSC/GBM cells can activate the SRC/AKT-YAP1 and YAP1/STAT3 pathways to upregulate the expression of chemokines (e.g., lysyl oxidase, CCL2, and CCL7), triggering macrophage migration and promoting tumor progression (13, 14). This evidence concerns the gene CCL2 and glioblastoma.