The scRNA-Seq data analysis in tumors from patients with GBM (47) demonstrated that CD44 expression in GSCs/GBM cells positively correlated with GPNMB expression level in TAMs but not in IMCs (Figure 5, A–D), suggesting a potential ligand-receptor interaction between TAMs and GSCs/GBM cells. This evidence concerns the gene GPNMB and glioblastoma.