In addition, amplification and overexpression of circadian locomotor output cycles kaput (CLOCK) in GSCs can transcriptionally upregulate the expression and secretion of olfactomedin like 3 (OLFML3) and legumain (LGMN) to stimulate microglia infiltration and immunosuppressive polarization, generating an environment promoting tumor growth (15, 16). This evidence concerns the gene OLFML3 and neoplasm.