GPNMB and glioblastoma: Using macrophage and microglia clustering in IDH1-WT TCGA GBM tumors (Supplemental Figure 5, B and C), we found that patients in the macrophage-high and microglia-high group exhibited poorer survival (Supplemental Figure 5, D and E) and higher GPNMB expression (Figure 7E) compared with patients in the macrophage-low and microglia-low group, respectively.