Next we sought to determine whether SiHa and CaSki cells exhibited ADAR1 dependency in terms of survival by analyzing available CRISPR/Cas9 datasets (24), and according to The Cancer Dependency Map (DepMap), ADAR1 appeared to have an essential function in both cell lines (Chronos score < –0.5) (Supplemental Figure 1C). Here, ADAR is linked to cancer.