Although an increased percentage of infiltrating CD45+ cells characterized both LSIL (44%) and CIS/IC (37%) compared with normal mucosa (32%), the frequency of innate CD7+ lymphocytes was significantly decreased in CIS/IC (from ~8% in normal mucosa, to ~7% in LSIL, and to ~3% in CIS/IC) (Figure 3, B and C). The gene discussed is PTPRC; the disease is in situ carcinoma.