Of these, there was a statistically significant difference in the incidence of any AE, any infection, serious infection, nasopharyngitis, upper respiratory tract infection, herpes zoster, hepatic disorder, increased CPK, neutropenia, lymphopenia, acne, malignancy other than NMSC and atopic dermatitis, upadacitinib 30 mg versus placebo. The gene discussed is PIK3C2A; the disease is Recurrent upper respiratory tract infections.