Some natural products, such as penthorum chinense pursh extract, green tea epigallocatechin gallate, have shown to treat MASLD by regulating the pyroptosis-related NLRP3/caspase-1/GSDMD pathway (Luo et al., 2024; Zhang et al., 2025). The gene discussed is CASP1; the disease is metabolic dysfunction-associated steatotic liver disease.