For example, erinacine A was seen to maintain astrocytic glutamate homeostasis through preservation of GLT-1 function and to increase expression of excitotoxicity protection machinery in a cerebral ischemia model (Hsu et al., 2022) whereas erinacine S was shown to increase accumulation of neurosteriods in primary cortical mouse neurons (Lin et al., 2023). This evidence concerns the gene SLC1A2 and Cerebral ischemia.