Additionally, other indicators, including gender, maternal age, age of onset, cesarean section rate, pregnancy‐induced hypertension, infants born to diabetic mothers, intrahepatic cholestasis of pregnancy, prenatal antibiotic use, premature rupture of membranes lasting over 18 h, and amniotic fluid fetal staining, did not significantly differ between groups EEN, LEN, and LEN1(p > 0.05). The gene discussed is SH3GL1; the disease is Intrahepatic cholestasis of pregnancy.