Amusingly, the iodinated dialkyl ammonium analogue is identified to be a better preclinical candidate than iodinated Cy7 with respect to dark cytotoxicity, light/dark cytotoxicity ratio, selectivity of localization in tumors over other organs, and clearance from the plasma.[18] Since the tumor‐seeking property is mainly attributed to covalent albumin binding, changing the indolium to benz[cd]indolium results in a long wavelength NIR‐II dye (compound 8, Figure 2), which can be easily bound to albumin and then forms a biomimetic NIR‐II fluorescent protein.[19]. This evidence concerns the gene ALB and neoplasm.