HMOX2 and neoplasm: Both in vitro and in vivo experiments indicated that compound 2 selectively seeks tumor initiating cells (TIC) through heme oxygenase 2 (HMOX2) with a dissociation constant (KD) of 0.38 μM.[6] Compound 3 (Figure 1), a meso‐S substituted asymmetry Cy7, has demonstrated better stability than ICG and also has some tumor‐seeking property.[7] Since ICG has many modifiable sites, it is reasonable to presume that more tumor‐seeking dyes derived from ICG will emerge.