It's known to accumulate in hepatocellular carcinoma (HCC) tissues after an intravenous injection, which means that ICG is an HCC tumor‐seeking dye.[4] Later research suggests that ICG accumulates in HCC tissues by organic anion transporting polypeptide 1B3 (OATP1B3) mediated uptake and its subsequent multidrug resistance p‐glycoprotein (MDR3) mediated excretion into dead‐ended pseudolands or bile canaliculi.[5]. Here, ABCB4 is linked to hepatocellular carcinoma.