To further investigate the relationship between EPDR1 and obesity, we divided serum EPDR1 levels into four quartiles based on its concentration in the entire cohort (Q1, <166.0 μg/ml; Q2, 166.0–201.0 μg/ml; Q3, 201.0–276.0 μg/ml, and Q4, >276.0 μg/ml). This evidence concerns the gene EPDR1 and obesity due to melanocortin 4 receptor deficiency.