AKT1 and Alzheimer disease: Mechanistic studies on the neuroprotective effects of anthocyanins indicate that Korean black bean anthocyanin (12 mg/kg/day for 30 days) regulates the phosphorylated phosphatidylinositol 3-kinase (p-PI3K)/protein kinase B (Akt)/glycogen synthase kinase 3β (GSK3β) pathway, thereby reducing ROS levels and oxidative stress in the brains of APP/PS1 transgenic mice, which improves cognitive function in these AD models.