In NAFLD, hepatocytes, stressed by lipotoxicity, and immune cells, such as Kupffer cells, release pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and interleukin-1β (IL-1β), which amplify hepatic inflammation (7, 8). The gene discussed is CRP; the disease is metabolic dysfunction-associated steatotic liver disease.